I go I-20 to I-26 to downtown, then 277 back to twenty every morning between 7:00 and 7:30 and it's usually not bad... but I won't hit interstate until Newberry exit, and I think it should be just the right time to eat breakfast and miss the Spartanburg rush. I'm hoping to get to Evarts not too long after noon.
I'd worry more about Asheville than Spartanburg personally. Noon will be a great time to get there. Will give you plenty of time to settle in and hit some trails Thursday.
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